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Institute of Ophthalmology, University College London

Professor Pete Coffey

Director of the London Project.

Key achievements

Seminal work (as described by Debrossy & Dunnett, Nature Neuroscience 2001) on retinal transplantation.

Principle author and co-author of two landmark papers demonstrating the use of human cells to halt visual deterioration in models of Age-related macular degeneration.

Use of human embryonic stem cells for age-related macular degeneration and retinitis pigmentosa.

1st international transplantation strategy for inherited macular dystrophy.

The development of a cell based therapy for currently untreatable age-related macular degeneration (dry AMD).

Key publications

  • Ramsden, C. M., Powner, M. B., Carr, A. J., Smart, M. J., da Cruz, L. & Coffey, P. J.. (2014.) Neural retinal regeneration with pluripotent stem cells. Dev Ophthalmol 53: 97-110.
  • Parfitt, D. A., Aguila, M., McCulley, C. H., Bevilacqua, D., Mendes, H. F., Athanasiou, D., Novoselov, S. S., Kanuga, N., Munro, P. M., Coffey, P. J., Kalmar, B., Greensmith, L. & Cheetham, M. E.. (2014). The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa. Cell Death Dis 5: e1236.
  • Muthiah, M. N., Keane, P. A., Zhong, J., Gias, C., Uppal, G., Coffey, P. J. & da Cruz, L.. (2014). Adaptive optics imaging shows rescue of macula cone photoreceptors. Ophthalmology 121: 430-431.
  • Muthiah, M. N., Gias, C., Chen, F. K., Zhong, J., McClelland, Z., Sallo, F. B., Peto, T., Coffey, P. J. & da Cruz, L.. (2014). Cone photoreceptor definition on adaptive optics retinal imaging. Br J Ophthalmol doi: 10.1136/bjophthalmol-2013-304615.
  • Goh, P.A., Caxaria, S., Casper, C., Rosales, C., Warner, T.T., Coffey, P.J., and Nathwani, A.C. (2013). A Systematic Evaluation of Integration Free Reprogramming Methods for Deriving Clinically Relevant Patient Specific Induced Pluripotent Stem (iPS) Cells. PloS one 8, e81622.