Institute of Ophthalmology, University College London

Professor Pete Coffey

Pete Coffey boxed profile picAs Director of the London Project it is my responsibility to co-ordinate, direct and innovate the three research groups to successfully bring the project to the clinic.

 

 


Key achievements

Seminal work (as described by Debrossy & Dunnett, Nature Neuroscience 2001) on retinal transplantation.

Principle author and co-author of two landmark papers demonstrating the use of human cells to halt visual deterioration in models of Age-related macular degeneration.

Use of human embryonic stem cells for age-related macular degeneration and retinitis pigmentosa.

1st international transplantation strategy for inherited macular dystrophy.

The development of a cell based therapy for currently untreatable age-related macular degeneration (dry AMD).

 

Key publications

  • Peter J. Coffey, Carlos Gias, Caroline J. McDermott, Peter Lundh, Matthew C. Pickering, Charanjit Sethi, Alan Bird, Fred W. Fitzke, Annelie Maass, Li Li Chen, Graham E. Holder, Philip J. Luthert, Thomas E. Salt, Stephen E. Moss, and John Greenwood. Complement factor H-deficiency in aged mice causes retinal abnormalities and visual dysfunction. PNAS, October 16, 2007, 104(42): 16651-16656.
  • Anthony Vugler, Jean Lawrence, James Walsh, Amanda Carr, Carlos Gias, Ma’ayan Semo, Ahmad Ahmado, Lyndon da Cruz, Peter Andrews, Peter Coffey (2007). Embryonic stem cells and retinal repair. Mechanisms of Development 124, 807–829.
  • Scheiermann, C., Meda, P., Aurrand-Lions, M., Madani, R., Yiangou, Y., Coffey, P., Salt, T. E., Ducrest-Gay, D., Caille, D., Howell, O., et al. (2007). Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science 318, 1472-1475.
  • Coffey, P.J., Girman, S., Wang, S.M., Hetherington, L., Keegan, D.J., Adamson, P., Greenwood, J. and Lund, R.D. (2002). Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Nat Neurosci 5: 53-6.
  • Coffey, P.J., Lund, R.D., Adamson, P., Sauve, Y., Keegan, D.J., Girman, S.V., Wang, S., Winton, H., Kanuga, N., Kwan, A.S., Beauchene, L., Zerbib, A., Hetherington, L., Couraud, P.O., and Greenwood, J. (2001). Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats. Proc Natl Acad Sci U S A 98: 9942-7.

 

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